The neuropharmacokinetics of valproate in pentylenetetrazol-kindled conscious epileptic rat hippocampus

In the present communication, the neuropharmacokinetics of valproate in pentylenetetrazol-kindled epileptogenesis rat hippocampus have been examined by micordialysis. It was found that the maximum concentration and the area under the hippocampus concentration-time curve of valproate in pathological rats were significantly higher than those in the control group. Time to maximum concentration of valproate appeared at 45 min after drug administration, and then the concentration of valproate gradually declined. The results suggest that the pathological damages of rat brain induced by pentylenetetrazol may result in the increase of the valproate level in epileptic rat hippocampus, and the neuropharmacokinetic research of valproate in a chronic kindled conscious animal model with acute administration may help the clinic in the pharmacokinetic optimization of the valproate dosage schedule in epileptic patients.