The Effect of ACTH and Cortisone on the Quantitative Precipitin Reaction

Summary Rabbits were treated with ACTH and cortisone given in physiologically significant doses prior to and during the period of immunization with bovine serum albumin. The behavior of the reaction between the antigen and the antibodies thus engendered as studied by the quantitative precipitin technic was not inconsistent with that from control animals. ACTH caused a marked diminution of the antibody titer and cortisone an almost complete suppression.