Содержание липидов в мембранах почечной ткани у больных мочекаменной болезнью и вторичным пиелонефритом

We studied cytomembranes of the interstitial tissue of renal medullary layer obtained by lifetime biopsy of renal tissue in the course of pyelolithotomy in 46 patients with urolithiasis and secondary pyelonephritis. Biopsy structure was controlled by histological methods using standard staining. Basic phospholipids and cholesterol fractions in renal tissue cytomembranes were assayed in thin layer chromatography. The findings have showed significant changes in a nephron cytomembrane lipid phase in patient with urolithiasis and secondary pyelonephritis. There was a structural rearrangement of lipid biolayer of renal tissue cell membranes in response to microbial inflammation. Thus, use of membrane-stabilising drugs are grounded in patients with secondary pyelonephritis and urolithiasis.