Effects of single and combined application of anti‐cancer drugs on cervical adenocarcinoma

Background. Establishment of effective combination chemotherapy regimen for patients with an adenocarcinoma of the uterine cervix has been long-awaited because there has been no documentation concerning chemosensitivity of this tumor against conventional antitumor agents.Methods. To search for an effective combination regimen, 15 conventional antitumor drugs were tested for growth inhibitory effects on five different cervical adenocarcinoma cell lines. Results. Etoposide, mitomycin C, adriamycin, epirubicin, and vinblastine, were singularly effective. Effects of combination chemotherapy were also tested using the above five antitumor agents plus interferon-γ. Etoposide, mitomycin C, and interferon-γ were the most effective when given in combination.Conclusions. Combined treatment with the above three drugs seems worthy of consideration for clinical application.