On developing a novel mixed-unit microparticle system for controlled release

ABSTRACTIn this study, uniform microparticles were prepared using the highly efficient microfluidic spray drying technology, and then a flexible controlled release mixed-unit microparticle system was developed to meet various needs. A mathematical drug release model of the mixed system was established and two mixed formulations were used to testify the predictive ability when initial parameters were given. Results have proved that the proposed model could precisely predict the release rate of tested samples. In conclusion, the novel system for controlled release may provide a new option for modified release drugs and may have a good prospect in the industrial application.