Factors predicting complications after transrectal ultrasound guided prostate biopsy

Objective: To evaluate risk factors of major complications after transrectal ultrasound guided prostate biopsy. Materials and Methods: 688 patients who were suspected to have prostate cancer and underwent transrectal ultrasound-guided prostate biopsy (TRUS and Biopsy) at Siriraj hospital between July 2010 to October 2011 were enrolled in the study. The parameters of demographic data, antibiotic prophylaxis, patients preparation, biopsy technique and complications after procedure were recorded. Results: Major complication occurred in 27 patients (3.9%). These complications were as follows: infection in 12 patients (1.7%; three were acute prostatitis, three was epididymo-orchitis, seven were febrile urinary tract infection and one was urosepsis), bleeding in 8 patients (1.1%; six were massive hematuria, two were massive hematochezia) and vasovagal syncope in 7 patients (1.0%). Statistically significant risk factor were periprostatic nerve block and core number of needle biopsies more than 20 core. Conclusion: There was no mortality after TRUS and biopsy in this study. Periprostatic nerve block and core number of needle biopsies; more than 20 core were the risk factor of the major complications.