Is human epididymis protein 4 an effective tool for thedifferential diagnosis of benign and malignant endometrialtumours
2016
Purpose of investigation: This study was designed to evaluate
the use of human epididymis protein 4 (HE4) as a biomarker in
the differential diagnosis of malignant and benign endometrial
tumours. Materials and Methods: The study, conducted between
July 2009 and June 2014, included a total of 150 patients with
endometrioid adenocarcinoma and a control group of 150 patients
with benign endometrial lesions. The serum of all patients was
analyzed with respect to HE4 and CA125 levels. The median and
ranges of serum levels were determined in relation to
histological results. The statistical analysis procedure
employed in this study utilized logarithmic-transformed values
of biomarkers and logistic regression. Results: An analysis of
two groups of patients with different histologies yielded a
statistically significant difference (p-value < 0.05) only in
the case of HE4, in which case a cut-off value of 48.5 pmol/l
resulted in an achieved sensitivity of 87.8%, a specificity of
56.6%, and a negative predictive value of 81.1%. Conclusion: In
combination with clinical and ultrasound findings, HE4 could
help with the differentiation of prognostically varied patient
groups as well as with the decision-making process associated
with the development of individual treatment plans. However,
the optimal cut-off for HE4 has not been established yet and
further studies are needed.
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