RESISTANCE PATTERN OF BURKHOLDERIA PSEUDOMALLEI FROM CLINICAL ISOLATES AT DR. SAIFUL ANWAR GENERAL HOSPITAL, MALANG-INDONESIA

Burkholderia pseudomallei (B. pseudomallei) is the organism that causes meliodosis. This organism is widely spread in South East Asia and North Australia. Rigorous studies have been conducted for better understanding about this organism due to its high fatality rate. This study was performed to observe resistance pattern of B. pseudomallei from clinical isolates in Dr. Saiful Anwar General Hospital, Malang-Indonesia during period of 2011 until 2013. Methods: Isolates were confirmed as B. pseudomallei using VITEK-2. Confirmed isolates were subjected to antimicrobial sensitivity test using Kirby Bauer method. We observed every isolate’s resistance to antimicrobial agents of choice as suggested by Center of Disease Control and Prevention (CDC) to treat melioidosis (ceftazidime, meropenem, cotrimoxazole, doxycycline) with addition of amoxycillin-clavulanic acid as drug of choice in ceftazidime or meropenem allergy. Results: We found, that some isolates were resistant towards ceftazidime and meropenem. Resistance to amoxycillin-clavulanic acid, cotrimoxazole and doxycycline were also found in high rate. Further study and continuous surveillance about B. pseudomallei in Indonesia needs to be carried out for better understanding about melioidosis and its potential therapy.