New paspalinine derivatives with antiinsectan activity from the sclerotia of Aspergillus nomius

Abstract 14-Hydroxypaspalinine ( 3 ) and 14-(N,N-Dimethyl-L-valyloxy)paspaline ( 4 ) have been isolated from the sclerotia of Aspergillus nomius , and identified by analysis of 2D NMR data. Both compounds cause ca . 90% reduction in weight gain in assays against the corn earworm Helicoverpa zea at the 100 ppm (dry weight) dietary level. Paspaline causes no effect at this concentration.