VENTILATOR-ASSOCIATED PNEUMONIA

Background: Patients associated with VAP having mortality rates range from 20to 50% and this may extend up to 70% when multi-resistant and invasive pathogens accountablefor infection, however, VAP is also interrelated with noteworthy rate of morbidity, extendedperiod of stay in ICU, protracted MV, and augmented hospitalization cost. Objectives: To reviewthe risk factors, incidence and transience rate of mortality for ventilator-associated pneumonia.Design: Prospective and cross sectional way. Period: From April 2016 to December 2016.Setting: Different Tertiary Care Institutes of Karachi, Pakistan. Method: A structured datacollection form was prepared to record the information and validated using spearman correlationcoefficient and Cronbach’s α value. Value of α = 0.902 and p = 0.913 have revealed the suitabledegree of reliability and uniformity. Data was collected with respect to gender, age, antibioticutilization record, and main diagnosis outcomes. Microbiological basis of ventilator-associatedpneumonia was assessed using patient lab record for rate and seclusion of organism. Results:In this study a detail of significant virulence factor articulated by these microorganisms hasbeen depicted. Statistically insignificant differences were observed among the groups withrespect to clinical and demographic characteristics like mean age, gender, infection severityscores (SOFA, MODS, CPIS and APACHE II), immune status of patients and type of the casesincluding surgical or clinical scenario. 39.3% patients developed early onset while 60.6% ofcohort was observed with late onset of VAP. Conclusion: The precise microbial source of VAPare numerous and diverse. The realistic challenge at the present time is to portray the authenticapproximate of the clinical consequences associated with VAP. Henceforth such investigationsmay be supportive in origination of the most favorable institutional antimicrobial strategy toreduce the associated complications of this threat.