Cellular Localization of Protein Arginine Methyltransferase-5 Correlates With Grade of Pulmonary Neuroendocrine Tumors

Epigenetic regulation plays an important role in oncogenesis. Histone modification is recognized as one strategy for modifying epigenetic control and cancer therapies. Cell culture and animal models show that protein arginine methyltransferase-5 (PRMT5) is an important epigenetic modifier of histone and nonhistone proteins in lymphomas, breast, colorectal, and lung cancer. Overexpression of PRMT5 is associated with malignant phenotype in …