A pair of novel 2,3-seco cafestol-type diterpenoid epimers from the twigs of Tricalysia fruticosa

Abstract A pair of 2,3- seco cafestol-type diterpenoid epimers, frutilactones A ( 1 ) and B ( 2 ) were isolated from twigs of Tricalysia fruticosa . Their structures were elucidated by comprehensively employing spectroscopic methods (MS and 1D/2D NMR) and ECD. Their inhibitory effects on nitric oxide production in lipopolysaccharide-activated macrophages were evaluated, and a possible biogenetic pathway was also proposed.