A method of preparing Ritonavir

A method of Ritonavir is prepared applied in technical field of medicine synthesis, under the conditions of organic base and organic solvent, using DIC as condensing agent, N- [N- methyl-N- [(2- isopropyl -4- thiazolyl) methyl] amino carbonyl]-Valine and (2S, 3S, 5S) -5- amino -2- (N- ((5- thiazolyl)-methoxycarbonyl group) amino) -1, the progress of 6- diphenyl -3- hydroxyhexane is reacted at amide, then post-processes to obtain Ritonavir through certain.The synthesis yield of Ritonavir has been significantly increased in the method for the present invention, and purity is high is effectively reduced the cost of raw material.It feeds intake simultaneously simple, does not need nitrogen protection, suitable control feed temperature, the by-product of reaction is easier to washed removing, substantially reduces preparation time, improve work efficiency, and is suitble to industrial production.