Correlation analysis and antimicrobial activities of substituted aryl imines

Substituted (E)-N-(4-bromobenzylidene) benzeneamines were synthesized using Fly-ash:PTS catalyzed solvent free reaction between 4-bromoaniline and substituted benzaldehydes. The synthesized Schiff's bases were characterized by UV, IR, 1H, and 13C NMR spectral data. These data were correlated with various Hammett substituent constants, F and R Swain-Lupton parameters using single and multi-regression analysis. From the results of statistical analysis, the effects of the substituents were studied. The antimicrobial activities of all the synthesized Schiff's bases were studied. The results of the study demonstrated the reaction protocol to be simple, eco-friendly, non-hazardous with easier work-up procedure and good yield. Good antimicrobial activity was observed in all imines against bacterial and fungal strains.