Ruige pirfenidone salts and crystalline forms, the preparation method

The present invention relates to two formula (Ⅰ, Ⅱ) Ruige shown pirfenidone organic acid salt, i.e. 2-hydroxy Ruige Sorafenib ethanesulfonate (salt by West) and ethyl sulfonates. The present invention further relates to pirfenidone by Western Ruige salt (Formula Ⅰ) two polymorphs, designated Form A, Form B. The present invention further relates to pirfenidone Ruige ethanesulfonate (Formula Ⅱ) in two crystal forms, designated as polymorph [alpha], Form β. The present invention also discloses a Ruige pirfenidone toluenesulfonate new crystalline form, designated as Form N-1. The present invention also discloses a Ruige pirfenidone by Western salt form A, prepared sulfonates B, Form Ruige Fini ethyl α, β, Ruige Fini toluenesulfonate of Form N-1 method. The present invention is disclosed by West Ruige pirfenidone salt Form A, B, ethanesulfonate Ruige Fini polymorph α, β, Ruige Fini toluenesulfonate Form N-1 has X- characteristic absorption peaks ray powder diffraction and differential scanning calorimetry (DSC) characteristic absorption peak. Wherein Ruige Fini by Western salt Form A, ethanesulfonate Ruige Fini β polymorph and Ruige pirfenidone toluenesulfonate Form N-1 is stable, easy to absorb moisture, solubility .