Changes in hormonal therapy during the first 24 months of treatment: A longitudinal cohort study.

e599Background: Data are limited showing changes in patients’ use of androgen deprivation therapy (ADT) in routine clinical practice. Methods: In this non-interventional, longitudinal cohort study, we assessed the number and type of modifications of ADT during the first 24 months of treatment in France. At baseline and every 6 months, we collected clinical, biological and therapeutic data and any changes of ADT modality. Results: Between July 2011 and January 2015, 891 pts were evaluable at 24 months. Mean age was 74.1±8.7 years. Indications for ADT were: biochemical relapse after local treatment (21.4%), adjuvant to radiotherapy (RT) (31.6%), metastases (24.2%) and locally advanced tumor without local treatment (20.6%). Gleason score was > 7, 7(4+3), 7 (3+4) and < 7 in 33.6%, 23.1%, 26% and 17.3%, respectively. At 24 months, modification of ADT was reported in 390 pts (43.8%). Modifications of ADT according to indications are summarized in table below. The main types of modification concerned the formula...