Mechanisms of cardioprotective effect of uridine-5'monophosphate in acute heart ischemia

It was found that prophylactic treatment with uridine-5'-monophosphate led to the stabilization of energy metabolism in ischemic myocardium. This appeared in the restoration of ATP and creatine phosphate levels, which decreased 60 minutes after occlusion of the left coronary artery. UMP also prevented accumulation of lipid peroxidation products and antioxidant system dysfunction in the heart at the early stages of acute ischemia. It was established that 5-hydroxydekanoat, a selective blocker of mitochondrial ATP-dependent K+-channel, eliminated the protective effect of uridine-5'-monophosphate. It was concluded that these channels involve in the cardioprotective mechanism of this uridine nucleotide. This data agree with the results of our previously study which had shown the anti-ischemic and anti-arrhythmic effect of uridine-5'-monophosphate consisting in reduction of zone of ischemia and the amplitude ofT-wave on ECG and decrease of heart rhythm disturbances on the model of acute myocardial infarction.