Chromosome aberrations in an alpha‐fetoprotein‐producing hepatoblastoma

The cytogenetic findings of an alpha-fetoprotein (AFP)-producing hepatoblastoma in a 14-month-old girl are reported. Ten of 36 tumor cells were chromosomally abnormal, yielding the composite karyotype 47,XX,2q+, t(3;5)(p25;q31),dup(4)(q12q26), + 20. Three of the chromosomal abnormalities (2q +, break at 4q12, + 20) have been reported previously and might be of pathogenetic significance.