Identification of recurrent SMO and BRAF mutations in ameloblastomas

Robert West, Jonathan Pollack and colleagues identify mutations in either the Hedgehog pathway gene SMO or the MAPK gene BRAF in 24 of the 28 ameloblastoma samples studied. They found 9 of 11 SMO mutations in maxillary ameloblastomas, whereas 9 of 13 BRAF mutations were found in mandibular cases.