Pathogenicity of Ife virus for Swiss albino mice.

Only suckling mice succumbed to intracerebral inoculation with infectivity titres which decreased by age and average survival time increasing with age. Virus was not recovered from the lungs and kidney but in low titre it was obtained from the liver, spleen, heart and bloodat different days p.i. All organs examined showed evidence of complement fixing and immunofluorescent Ife virus antigen. No gross lesions were observed. The histopathological lesions were limited to the brain