Synthesis and biological activity of pyridopyridazin-6-one p38 MAP kinase inhibitors. Part 1.

Robert M. Tynebor,Meng Hsin Chen,Swaminathan R. Natarajan,Edward A. O’Neill,James E. Thompson,Catherine E. Fitzgerald,Stephen J. O’Keefe,James B. Doherty

Synthesis and biological activity of pyridopyridazin-6-one p38 MAP kinase inhibitors. Part 1.

2011

Robert M. Tynebor
Meng Hsin Chen
Swaminathan R. Natarajan
Edward A. O’Neill
James E. Thompson
Catherine E. Fitzgerald
Stephen J. O’Keefe
James B. Doherty

The development and synthesis of potent p38α MAP kinase inhibitors containing a pyridazinone platform is described. Evolution of the p38α selective pyridopyridazin-6-one series from the p38α/β dual inhibitor 2H-quinolizin-2-one series will be discussed in full detail.

Keywords:

Mitogen-activated protein kinase
Chemical synthesis
Enzyme
Biochemistry
Pyridopyridazin-6-one
Stereochemistry
Biological activity
Enzyme inhibitor
p38 mitogen-activated protein kinases
Chemistry
Molecular model

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