Genotoxicity and cytotoxicity assessment of new ethyl-carbamates with ixodicidal activity.

Abstract The mammalian erythrocyte micronucleus test was used on the peripheral blood of Wistar rats exposed to two new ethyl-carbamates: ethyl-4-bromophenyl-carbamate (LQM 919) and ethyl-4-chlorophenyl-carbamate (LQM 996) to analyze their genotoxic potential. The mitotic index and cell proliferation kinetics in human lymphocyte cultures in the presence of these ethyl-carbamates were used to evaluate cytotoxicity and cytostaticity respectively. Exposure to greater acute doses (300 mg/kg) and to all of the subchronic doses (12.5, 25 and 50 mg/kg daily for 90 days) of these ethyl-carbamates induced an increased frequency (p