A kind of preparation method of Idebenone

The present invention relates to a kind of preparation method of Idebenone, this method includes:Using coenzyme Q-10 and 11 hydroxyl undecanoic acids as raw material; a kind of metal salt in selective chlorination copper, copper sulphate, copper acetate, silver carbonate, silver oxide, palladium bichloride or acid chloride is used as catalyst; the oxidizer hydrogen peroxide under oxygen protection, occurs radical alkylation.Reaction system obtains yellow needle-like crystals, the methyl Isosorbide-5-Nitrae benzoquinones of 6 (10 hydroxydecyl) 2,3 dimethoxy 5, i.e. Idebenone through extraction, washing, drying, vacuum distillation, column chromatography.The preparation method has simple to operate, and cost is low, the advantages of yield is higher, it is adaptable to large-scale industrial production Idebenone.