New heterocycles having double characters as antimicrobial and surface active agents: Part 1-Nonionic compounds from fatty acid isothiocyanate

Fatty acids isothiocyanates 1 have been used as stalling materials to synthesise some important heterocycles, such as triazoles, oxazoles, thiazoles, benzoxazoles and quinazolines by treating with different types of nucleophiles, namely, nitrogen nucleophiles, oxygen nucleophiles and sulphur nucleophiles. The produced compounds react with propylene oxide in different moles (n = 3, 5 and 7) to yield novel groups of nonionic compounds having a double function like antimicrobial and surface active agents which can be used in the manufacture of drugs, cosmetics, pesticides or can be used as antibacterial and/or antifungal. The physical properties as surface and interfacial tension, cloud point, foaming height, wetting time, emulsification power and the critical micelle concentration (CMC) have been determined. Antimicrobial and biodegradability are also determined.