Structure of full-length human anti-PD1 therapeutic IgG4 antibody pembrolizumab
2015
IgG4 antibodies can exchange Fab arms and show different affinities for Fc receptors than do other IgG subclasses. The structure of full-length pembrolizumab, a human IgG4 approved to treat advanced melanoma, provides a framework to understand IgG4's properties.
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