Pro- and antioxidant properties of uracil derivatives

The review summarizes data on pro- and antioxidant properties of uracil derivatives comprising an important group of pharmacologically active compounds. The presence of OH or NH2 groups at position 5 of the uracil ring was shown to be essential for these compounds to have both antioxidant and prooxidant properties. The mechanism of pro- and antioxidant action is discussed.