NATURAL O-GLYCANS ON ATRIAL NATRIURETIC PEPTIDE ATTENUATE THE ACUTE RENAL AND CARDIOVASCULAR ACTIONS IN VIVO

The precursor of B-type natriuretic peptide (proBNP) is known to be O-glycosylated where the O-glycans substantially impact BNP biology. We have now identified O-glycans on the precursor of the related atrial natriuretic peptide (ANP) and ANP itself. To date, the biological impact of O-glycans on