Monolith-based 68Ga processing: a new strategy for purification to facilitate direct radiolabelling methods

The post-processing of 68Ga generator eluate by means of a novel high capacity cation-exchange silica monolith column has been validated in this work. Quantitative release of a purified 68Ga solution in high concentration can be achieved using weak acidic solutions which can be directly used for chelator or conjugate labelling in an injectable form with improved radiochemical characteristics. The system has the potential to be incorporated in a flow based microfluidic system for dose-on-demand radiotracer synthesis.