Characterisation of the TCR repertoire in NSCLC to reveal the relationship between TCR heterogeneity and genetic heterogeneity that is influenced by mutational load and is associated with disease recurrence.

Kroopa Joshi,Mazlina Ismail,James L. Reading,Marc Robert De Massy,Imran Uddin,Mariam Jamal-Hanjani,Selvaraju Veeriah,Theres Oakes,Yien Ning Sophia Wong,Andrew James Scott Furness,Ehsan Ghorani,Andrew Georgiou,Carmella Beastall,Nagina Mangal,Assma Ben Aissa,Mariana Werner Sunderland,Karl S. Peggs,Charles Swanton,Benjamin M. Chain,Sergio A. Quezada

Characterisation of the TCR repertoire in NSCLC to reveal the relationship between TCR heterogeneity and genetic heterogeneity that is influenced by mutational load and is associated with disease recurrence.

2018

12009Background: The lung TRACERx study is a prospective study exploring the cancer genome evolution of NSCLC. Data analysis from the first 100 patients enrolled into the study has shown an increas...

Keywords:

Genetic heterogeneity
Pathology
Repertoire
T-cell receptor
Disease
Cancer research
Medicine
Immunology
cancer genome
Prospective cohort study
tcr repertoire

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