Late-onset male hypogonadism and testosterone replacement therapy in primary care

: LOMH is frequently observed in primary care, with an increasing prevalence in older men. The diagnosis is based on a combination of mostly nonspecific signs and symptoms and measurement of testosterone and other hormones. Various testosterone formulations are available to individualize therapy to restore the physiologic testosterone level and improve symptoms. Careful assessment must be undertaken prior to and during TRT to prevent harm, reduce adverse events, and foster adherence.