Effect of different delivery modes on mother-to-infant transmission of hepatitis B virus

Objective To explore the effect of different delivery modes on the mother-to-infant transmission of hepatitis B virus for the mothers with hepatitis B surface antigen(HBsAg)seropositive and hepatitis B e antigen(HBeAg)seropositive. Methods A total of 215 HBsAg and HBeAg seropositive mothers and their neonates(n=216)entered the study.According to delivery mode,216 children were divided into vaginal delivery group(n=102) and caesarean section group(n=114).Serum HBV-markers were detected in 7-month old children and were compared between two groups. Results The positive rates of HBsAg were 5.9% and 4.4% in delivery group and section group,and the positive rates of HBsAb were 94.1% and 95.6%,respectively(χ2=0.249,P=0.617). Conclusion The delivery modes have no significant difference in blocking the mother-to-child transmission of HBV.