Vitamin D Levels in Full-Term Neonates with Indirect Hyperbilirubinemia

Background: Jaundice is a common clinical sign in neonatal medicine. Considering the different roles of vitamin D, its lower level may be correlated with neonatal jaundice. Objectives: This study aimed to demonstrate the relationship between serum vitamin D level and neonatal hyperbilirubinemia and to measure its level in their mothers. Subjects and methods: This case-control study was conducted on 90 neonates and their mothers, 60 neonates with hyperbilirubinemia in patients group and 30 healthy neonates age and sex matched in control group . Blood samples from neonates and their mothers were obtained and sent for laboratory estimation of 25-hydroxy vitamin D, calcium, magnesium, phosphorus, alkaline phosphatase and parathyroid hormone. Results: There is highly significant decrease of vitamin D levels among patients than controls, significant negative correlation between vitamin D levels and serum bilirubin in neonates and no significant difference regarding different laboratory parameters among their mothers. Conclusion: Decreased levels of vitamin D were significantly correlated with neonatal indirect hyperbilirubinemia so, low vitamin D can be included among risk factors for neonatal jaundice.