Beneficios en la microbiota intestinal después de la suplementación con inulina y la goma guar parcialmente hidrolizada: un ensayo clínico aleatorizado en mujeres con estreñimiento
2012
Introduction: Prebiotics positively affect gut microbiota
composition, thus improving gut function. These
properties may be useful for the treatment of constipation.
Objectives: This study assessed the tolerance and effectiveness
of a prebiotic inulin/partially hydrolyzed guar
gum mixture (I-PHGG) for the treatment of constipation
in females, as well as its influence on the composition of
intestinal microbiota and production of short chain fatty
acids.
Methods: Our study enrolled 60 constipated female
health worker volunteers. Participants reported less than
3 bowel movements per week. Volunteers were randomized
to treatment with prebiotic or placebo. Treatment
consisted of 3 weeks supplementation with 15 g/d IPHGG
(fiber group) or maltodextrin (placebo group).
Abdominal discomfort, flatulence, stool consistency, and
bowel movements were evaluated by a recorded daily
questionnaire and a weekly interview. Changes in fecal
bacterial population and short chain fatty acids were
assessed by real-time PCR and gas chromatography,
respectively.
Results: There was an increased frequency of weekly
bowel movements and patient satisfaction in both the
fiber and placebo groups with no significant differences.
Total Clostridium sp significantly decreased in the fiber
group (p = 0.046) and increased in the placebo group (p =
0.047). There were no changes in fecal short chain fatty
acid profile.
Conclusions: Consumption of I-PHGG produced clinical
results comparable to placebo in constipated females,
but had additional protective effects on gut microbiota by
decreasing the amount of pathological bacteria of the
Clostridium genera.
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