НОСИТЕЛЬСТВО МУТАЦИЙ В ГЕНАХ BRCA1 И BRCA2 У ЗДОРОВЫХ ЖЕНЩИН И МУЖЧИН: ДНК-ТЕСТИРОВАНИЕ, ДИАГНОСТИЧЕСКИЕ МЕРОПРИЯТИЯ И ПРОФИЛАКТИКА РАКА

BRCA1 and BRCA2 germ-line mutations are associated in increased cancer risk both in women and in men. This article summarizes clinical recommendation of European Society for Medical Oncology (ESMO), National Comprehensive Cancer Network (NCCN) and other professional societies regarding inclusion criteria for BRCA-testing, diagnostic activities aimed to detect early cancers in BRCA1/2 mutation carriers as well as approaches to prevention of BRCA-driven cancers. The adjustment of existing clinical recommendations to health care realities in Russian Federation is discussed