Griseofulvin-Hydrogenated Soya Phospholipid Coprecipitates

AbstractThe dissolution of griseofulvin was accelerated significantly by formulation as a griseofulvin-hydrogenated soya phospholipid coprecipitate. The transport of griseofulvin across both cellulose membranes and rat intestinal sac was also accelerated by the use of coprecipitates. X-ray diffraction data suggest that the decrease in crystallinity of griseofulvin in the coprecipitate accelerated the dissolution of griseofulvin. The possible aggregation (possible small micelle formation) of phospholipid including griseofulvin in water may also increase the apparent solubility of griseofulvin from the coprecipitate. The increase in surface area of coprecipitate and pure griseofulvin by including bulking (core) substances further accelerated the dissolution of griseofulvin and resulted in rapid transport of griseofulvin through cellulose membranes.