Genotyping upper gastrointestinal cancer in daily clinical care.

e15004 Background: Cancer is driven by somatic genetic alterations. Recently molecular subtypes have been identified in a number of different cancer types such as lung cancer, melanoma or GIST. Little is known on the distribution of genetic subtypes of upper gastrointestinal cancer in daily routine. Methods: We build up a molecular diagnostics platform for patients with incurable upper gastrointestinal tumors starting Q1/13 at our center for GI cancer in Cologne. In addition, several participating private practices and non-academic hostpitals are offered a comprehensive panel of molecular diagnostic (FGFR1, FGFR2, MET, ERBB2, KRAS, NRAS, BRAF, PIK3CA, TP53, MSI). Pathological reports are send back including a treatment recommendation. Results: Molecular diagnostics on the first 156 consecutive patients (Oesophageal cancer 108, gastric cancer 47) are presented. In squamous cell esophageal cancer the following frequencies of genetic alterations were observed: TP53 mut 89%, NFE2L2 25%, KEAP1 17%, PIK3CA 14%,...