Changes in Erythrocyte Membrane in Type-2 Diabetes Mellitus with and without Dyslipidemia

Background: In Diabetes mellitus there is decreased number of pump units on the erythrocyte membrane, altered lipid – protein interaction, depleted membrane anionic charge and enzyme glycation and peroxidation which account for many abnormal complications. Method: Diabetes subjects with and without dyslipidemia were selected along with healthy control then we correlate the changes in serum and erythrocyte membrane. Result: The lipid composition of membrane is significantly increased with cholesterol:phospholipid ratio and Na + K + - ATPase of membrane was decreased when compared to control. Conclusion: Lipid composition disturbances along with increased hyperglycemia which causes glycation of enzymes and oxidative stress causes the decrease in activity of Na + K + -ATPase and other changes in erythrocyte membrane.