Effect of vertebrate hypoglycemic and β-cell cytotoxic agents on insects☆

The effect of several vertebrate hypoglycemic and fl-cell cytotoxic chemicals on insects was examined. 2. The dietary LCs0's for phenformin fed to Manduca sexta, Plodia interpunctella, and Tribolium confusum were 1.4 x 10 3, 3.3 x 10 a and 13.0 x 103 ppm. 3. Chlorpropamide and tolbutamide were similarly effective against M. sexta at 8.5 x 103 and 17 x 103 ppm. 4. Chlorpropamide produced a 23% hypotrehalosemic response in M. sexta fed 104 ppm supple- mented diet. 5. The fl-cell cytotoxic agents, alloxan and streptozotocin, produced 50% mortality when injected into the hemocoel of fourth-instar M. sexta at doses of 150 and 85 ~ug/g body weight.