Hypofibrinogenemia caused by adrenocorticotropic hormone for infantile spasms: A case report

Abstract We report the case of a 7-month-old boy who developed hypofibrinogenemia (66.6 mg/dL; reference value, 170–405 mg/dL) during adrenocorticotropic hormone (ACTH) therapy for infantile spasms. Although the patient showed no clinical signs of a bleeding diathesis, we recommend that plasma fibrinogen levels should be monitored during ACTH therapy, which should be discontinued when fibrinogen levels fall below hemostatic levels (60.0 mg/dL) or when bleeding tendencies are recognized.