Is adjuvant chemotherapy for non-small cell lung cancer here to stay?

▴ Winton T, Livingston R, Johnson D, et al . Vinorelbine plus cisplatin vs observation in resected non-small cell lung cancer. N Engl J Med2005;352:2589–97 [OpenUrl][1][CrossRef][2][PubMed][3][Web of Science][4] In this study patients with completely resected stage IB or stage II non-small cell lung cancer were randomised to either adjuvant chemotherapy with vinorelbine and cisplatin (n = 242) or to observation (n = 240). The primary end point was overall median survival which was significantly prolonged in the chemotherapy group (94 v 73 … [1]: {openurl}?query=rft.jtitle%253DNew%2BEngland%2BJournal%2Bof%2BMedicine%26rft.stitle%253DNEJM%26rft.issn%253D0028-4793%26rft.aulast%253DWinton%26rft.auinit1%253DT.%26rft.volume%253D352%26rft.issue%253D25%26rft.spage%253D2589%26rft.epage%253D2597%26rft.atitle%253DVinorelbine%2Bplus%2BCisplatin%2Bvs.%2BObservation%2Bin%2BResected%2BNon-Small-Cell%2BLung%2BCancer%26rft_id%253Dinfo%253Adoi%252F10.1056%252FNEJMoa043623%26rft_id%253Dinfo%253Apmid%252F15972865%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/external-ref?access_num=10.1056/NEJMoa043623&link_type=DOI [3]: /lookup/external-ref?access_num=15972865&link_type=MED&atom=%2Fthoraxjnl%2F60%2F9%2F729.atom [4]: /lookup/external-ref?access_num=000229953700006&link_type=ISI