Study on Anti-Tumor Network Mechanism of Miao National Herbs Periploca Forrestii

In this study, tumor disease targets and periploca forrestii(PF) associated targets were determined through the use of databases for the identification of putative therapeutic targets and then combined. After the interaction network of therapeutic targets against tumor was established, and the core targets against tumor were determined by degree analysis. For all putative therapeutic targets, analyses of biological function were performed to optimize the biological processes and key signaling pathways of PF in tumor treatment. The top 5 therapeutic targets were identified, including AKT1, TP53, PTGS2, AR and AHR. The biological processes associated with the antitumor activity of PF were mainly associated with positive regulation of cell proliferation, trypsis response, transcription of DNA templates andpositive regulation of transcription from RNA polymerase II promote regulation; and signaling pathways associated with the antitumor activity of PF are mainly associated with influenza A signaling pathway, PI3K-Akt signaling pathway, and HTLV-I infection signaling pathway.