Discovery of RO7185876, a highly potent γ-secretase modulator (GSM) as a potential treatment for Alzheimer’s disease

Hasane Ratni,André Alker,Bjoern Bartels,Caterina Bissantz,Weichun Chen,Irene Gerlach,Anja Limberg,Mingqiu Lu,Werner Neidhart,solen pichereau,Michael Reutlinger,Rosa Maria Rodriguez-Sarmiento,Roland Jakob-Rœtne,Georg Schmitt,Eric Zhang,Karlheinz Baumann

Discovery of RO7185876, a highly potent γ-secretase modulator (GSM) as a potential treatment for Alzheimer’s disease

2020

Hasane Ratni
André Alker
Bjoern Bartels
Caterina Bissantz
Weichun Chen
Irene Gerlach
Anja Limberg
Mingqiu Lu
Werner Neidhart
solen pichereau
Michael Reutlinger
Rosa Maria Rodriguez-Sarmiento
Roland Jakob-Rœtne
Georg Schmitt
Eric Zhang
Karlheinz Baumann

δ-Secretase (GS) is a key target for the potential treatment of Alzheimer’s disease. While inhibiting GS led to serious side effects, its modulation holds a lot of potential to deliver a safe trea...

Keywords:

Biology
GSM
Pharmacology
Disease
γ secretase modulator

Correction
Source
Cite
Save
Machine Reading By IdeaReader

References

Citations