Advances in the structure-activity relationship study of natural flavonoids and its derivatives

Flavonoids are a large class of compounds widely distributed in nature.Many pharmacological activities of flavonoids have been reported such as anti-cancer,antioxidant,anti-inflammatory,hepatoprotective,antithrombotic,vasodilator,antiviral,antibacterial,antiallergic,and so on.In recent years,domestic and foreign research groups choose natural flavonoids and optimize their chemical structures in order to develop a number of new derivatives with stronger pharmacological activities.As part of the mechanisms are not clear,we need to strengthen in-depth research in the SAR(structure-activity relationship) study for targeted and efficient structure optimization.This paper systematically summarize current researches in the SAR studies of flavonoids and their derivatives,which can serve as a reference for synthesizing new flavonoid derivatives.