SOME UNTOWARD EFFECTS ASSOCIATED WITH THE USE OF THE BIOPREPARATION FROM Picralima nitida SEEDS EXTRACT AS ANTIDIABETIC AGENT

Summary of the severity of lesions in the pancreas in the various treatment groups LESIONSGROUPS 123456 7 Necrosis of exocrine and fat cells – ++ – + + + +Enlarged islet of langerhans – ++ – +++ +++ +++ +Hyperplastic ducts and ductular proliferation – – – +++ +++ ++ +Blockage of ductular lumen by inflammatory cells – ++ – + ++ ++ ++Thickening of the walls of the tubules and vessels – – – ++ +++ ++ +Peri-vascular necrosis and fibrosis – – – ++ +++ ++ ++Vascular degeneration of the cells of the islets and fat cells – – – + + +++ + Notes: – not present; + mild; ++ moderate; +++ severe. Fig. 11. Photomicrograph of the pancreas section: showing of normal appearance of the langerhans isletsf ( IL ) in the pancreas of normal control groups. 400 H&E Fig. 12. Photomicrograph of a section of the pancreas: showing degeneration of the langerhans islets ( DI ) and thickened duct ( TD ). 100 H&EPANCREAS: hyperplastic ductular wall Fig. 13. Photomicrograph of a section of the pancreas: showing mild hyperplasia (