MO217ASSOCIATION BETWEEN SERUM VITAMIN-D LEVEL WITH LUNG INVOLVEMENT AND OUTCOME IN COVID-19 PNEUMONIA

Background and Aims Vitamin D deficiency has been reported as a key factor in the development of infectious diseases such as respiratory tractinfections and inflammatory processes like acute respiratory distress syndrome. However, the impact of vitamin D on these verity and outcome of COVID-19 is still not fully known. Herein, we aimed to evaluate the prognostic role of serumvitamin D concentration on the extent of lung involvement and final outcome in patients with COVID-19. Method Seventy-three subjects with confirmed diagnosis of COVID-19were investigated in this study. The patients had been admittedto our academic hospital from February 28, 2020 to April 19,2020. Demographic and clinical data, serum 25(OH)D levels, and findings of initial chest computed tomography were recorded. Linear and binary logistic regression, cox regression and ROCcurve tests were used for statistical analysis. Results The mean age of patients was 55.18 14.98 years old;46.4%were male. Mean serum 25(OH)D concentration was significantly lower in the deceased (13.8312.53 ng/ mLcompared with discharged patients (38.4118.51 ng/mL) (P < 0.001). Higher levels of 25(OH)D were associated with significantly less extent of total lung involvement (β = - 0.10, P =0.004). In addition, vitamin D deficiency [25(OH) D < 25 ng/mL]was associated with a significant increase in the risk of mortality (hazard ratio = 4.15, P = 0.04). Conclusion This study suggests that serum vitamin D status might provide useful information regarding the clinical course, extent of lung involvement and outcome of patients with COVID-19. How ever, further studies with larger sample size are needed to confirm these findings. Log minus log of hazard function. The evaluation of the assumption of proportionality of hazards in cox survival models. The parallel log minus logfunctions in 25(OH)D deficiency groups and Schoenfeld residues analysis(chi-square = 8.02, DF = 4, P = 0.10) indicates that comparing hazard of deathin two groups does not depend on time and the proportionality assumptionis hold in cox regression a-c A 55-year-old man presented with 5-day history of fever and dry cough without any comorbidity [25(OH)D level was 40 ng/mL] with initial lung computed tomography (CT) involvement score of eight/24. On admission, CTimages showed subtle patchy groundglass opacities (GGO) (long arrows)predominantly in upper zones and reticular pattern (wide arrows) in lowerzones. The patient discharged aft er 6 days. d-f A 54-year-old man presented with 4-day history of fever, dry cough and dyspnea and no other comorbidity[25(OH)D level was 7 ng/mL]. Lung CT score involvement score of ninety/24.On admission, CT images showed diff use GGO (long arrows) with slightconsolidation change (thick head arrow) in right mid zone. The patient diedaft er 19 days.