Asymmetric synthesis of both enantiomers of two acyclic nucleoside analogues related to d4T and acyclovir
2002
Abstract The enantiomers of 1-{[(2-hydroxy-1-phenyl)ethoxy]methyl}thymine and 9-{[(2-hydroxy-1-phenyl)ethoxy]methyl}guanine have been obtained in high yield in five steps from ( R )- and ( S )-1-phenylethan-1,2-diol. These chiral compounds are acyclic nucleoside analogues of d4T and acyclovir, respectively.
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