Epitope spreading of the anti-citrullinated protein antibody response occurs before disease onset and is associated with the disease course of early arthritis

Diane van der Woude,Solbritt Rantapää-Dahlqvist,Andreea Ioan-Facsinay,Carla Onnekink,Carla M. Schwarte,Kirsten N Verpoort,Jan W. Drijfhout,Tom Huizinga,Rene Toes,Ger J. M. Pruijn

Epitope spreading of the anti-citrullinated protein antibody response occurs before disease onset and is associated with the disease course of early arthritis

2010

Diane van der Woude
Solbritt Rantapää-Dahlqvist
Andreea Ioan-Facsinay
Carla Onnekink
Carla M. Schwarte
Kirsten N Verpoort
Jan W. Drijfhout
Tom Huizinga
Rene Toes
Ger J. M. Pruijn

Background Anti-citrullinated protein antibodies (ACPA) are the most predictive factor for the development of rheumatoid arthritis (RA). Objective To investigate whether the recognition of citrulli ...

Keywords:

Connective tissue disease
Anti–citrullinated protein antibody
Epitope
Antibody
Rheumatology
Rheumatoid arthritis
Arthritis
Immune system
Immunology
Medicine
Internal medicine

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