PP061: Genetic expressions of ER/PR and HER2/neu among salivary gland tumour patients at UCH Ibadan

Purpose Acinar and ductal structures are found in normal breast and salivary gland tissue, also similar histopathological findings were revealed by some neoplasm from these tissues therefore the role of ER/PR and HER2/neu as molecular targets in breast cancer were projected to salivary gland tumours (SGT’s). The purpose of this study was to determine the levels of expression of these genes which may be indicators for targeted therapy in SGT’s. Materials and methods The study utilised sections of hematoxylin-eosin (HE mean 45.4 ± 16.6 years) there were 15 benign and 25 malignant cases. There was a definite increased positive expression of oestrogen receptor with increasing clinical stage ( x 2  = 5.6; p  = 0.00) and higher histological grades irrespective of sex and histological type ( X 2  = 4.2; p  = 0.04 Fisher’s exact) while the positive expression of PR was generally low irrespective of sex, clinical stage, histological type and grade of malignant SGT’s. There was lack of positive expression of HER2/neu among all benign SGT’s while only one high grade acinic cell carcinoma showed minimal positive expression among the malignant SGT’s. Conclusions ERα receptor may be a suitable molecular target for therapy of high grade malignant SGT that show positive expression, the role of PR receptor targeted therapy is doubtful in malignant SGT’s. None of the SGT’s showed convincing positive HER2/neu expression.