Progress of long non-coding RNA in non-small cell lung cancer

Lung cancer is the leading cause of cancer-related deaths worldwide, among which more than half of non-small cell lung cancer had been locally advanced or distant metastasis at the time of diagnosis. Therefore, it has a poor prognosis. In recent years, long non-coding RNA (lncRNA) has drawn great attention in the field of oncology. Abnormally expression of lncRNA plays an important role in the development of non-small cell lung cancer through different transcriptional, post-transcriptional or epigenetic mechanisms. This review summarizes the current literature on lncRNA in non-small cell lung cancer, introduces the functions and influences of lncRNA in the biology of non-small cell lung cancer and highlights its clinical potential value as a tumor biomarker and potential therapeutic target. Key words: Carcinoma, non-small-cell lung; Review; Long non-coding RNA