Myokine: a novel target for exercise to improve cognitive function?

Recently, we read with great interest the paper by Zheng et al ,1 in which the authors who performed an excellent meta-analysis concluded that aerobic exercise had a physiological benefit to improve cognitive function in patients with mild cognitive impairment. We appreciate this finding and would like to present a hypothesis that myokine triggered by physical aerobic exercises might also play a pivotal role in the improvement of cognitive impairment. Physical exercise is of great importance to the health of brain. Increasing evidence shows that regular exercise could increase the activity of skeletal muscle and, as a …